DNA methylation (DNAm) is an epigenetic regulator of gene expression and a hallmark of gene-environment interaction. Using whole-genome bisulfite sequencing, we have surveyed DNAm in 344 samples of human postmortem brain tissue from neurotypical …
Numerous DNA methylation (DNAm) biomarkers of cigarette smoking have been identified in peripheral blood studies, but because of tissue specificity, blood-based studies may not detect brain-specific smoking-related DNAm differences that may provide …
By combining RNA-sequencing and DNA methylation data across four brain regions of neurotypical (N=49) and Alzheimer\'s disease patients (N=24), we were able to identify new genes associated with Alzheimer\'s disease.