DNA methylation (DNAm) is an epigenetic regulator of gene expression and a hallmark of gene-environment interaction. Using whole-genome bisulfite sequencing, we have surveyed DNAm in 344 samples of human postmortem brain tissue from neurotypical …
**Background:** Gulf War (GW) Illness (GWI) is a debilitating condition with a complex constellation of immune, endocrine and neurological symptoms, including cognitive impairment, anxiety and depression. We studied a novel model of GWI based on 3 …
Quantification of gene expression and characterization of gene transcript structures are central problems in molecular biology. RNA sequencing (RNA-Seq) and chromatin immunoprecipitation sequencing (ChIP-Seq) are important methods, but can be …
Human induced pluripotent stem cells (hiPSCs) are a powerful model of neural differentiation and maturation. We present a hiPSC transcriptomics resource on corticogenesis from 5 iPSC donor and 13 subclonal lines across 9 time points over 5 broad …
Numerous DNA methylation (DNAm) biomarkers of cigarette smoking have been identified in peripheral blood studies, but because of tissue specificity, blood-based studies may not detect brain-specific smoking-related DNAm differences that may provide …
We explored the association between schizophrenia GWAS risk at locus 11q25 and local transcript expression of SNX19. We identified a prominent class of GWAS risk-associated SNX19 transcripts defined by an exon-exon splice junction. Further work suggests local epigenetic marks mediate the effect of risk variants on local SNX19 risk transcript expression.
By combining RNA-sequencing and DNA methylation data across four brain regions of neurotypical (N=49) and Alzheimer\'s disease patients (N=24), we were able to identify new genes associated with Alzheimer\'s disease.
The hippocampus formation, although prominently implicated in schizophrenia pathogenesis, has been overlooked in large-scale genomics efforts in the schizophrenic brain. We performed RNA-seq in hippocampi and dorsolateral prefrontal cortices (DLPFCs) …
We investigated the effects of smoking-exposure on prenatal and adult gene expression in the frontal cortex. We found developmentally-dependent gene expression differences between smoking-exposed and -unexposed brains. These expression differences were enriched for the gene signatures of autism spectrum disorder.