Schizophrenia

Genome-wide sequencing-based identification of methylation quantitative trait loci and their role in schizophrenia risk

DNA methylation (DNAm) is an epigenetic regulator of gene expression and a hallmark of gene-environment interaction. Using whole-genome bisulfite sequencing, we have surveyed DNAm in 344 samples of human postmortem brain tissue from neurotypical …

Schizophrenia risk variants influence multiple classes of transcripts of sorting nexin 19 (SNX19)

We explored the association between schizophrenia GWAS risk at locus 11q25 and local transcript expression of SNX19. We identified a prominent class of GWAS risk-associated SNX19 transcripts defined by an exon-exon splice junction. Further work suggests local epigenetic marks mediate the effect of risk variants on local SNX19 risk transcript expression.

Regional Heterogeneity in Gene Expression, Regulation, and Coherence in the Frontal Cortex and Hippocampus across Development and Schizophrenia

The hippocampus formation, although prominently implicated in schizophrenia pathogenesis, has been overlooked in large-scale genomics efforts in the schizophrenic brain. We performed RNA-seq in hippocampi and dorsolateral prefrontal cortices (DLPFCs) …