DNA methylation (DNAm) is an epigenetic regulator of gene expression and a hallmark of gene-environment interaction. Using whole-genome bisulfite sequencing, we have surveyed DNAm in 344 samples of human postmortem brain tissue from neurotypical …
We explored the association between schizophrenia GWAS risk at locus 11q25 and local transcript expression of SNX19. We identified a prominent class of GWAS risk-associated SNX19 transcripts defined by an exon-exon splice junction. Further work suggests local epigenetic marks mediate the effect of risk variants on local SNX19 risk transcript expression.
The hippocampus formation, although prominently implicated in schizophrenia pathogenesis, has been overlooked in large-scale genomics efforts in the schizophrenic brain. We performed RNA-seq in hippocampi and dorsolateral prefrontal cortices (DLPFCs) …